Improving the care of patients suffering from acute or chronic pain

There is a very high need for improving health care for the management of pain, which is the scope of this Topic. As acute and persistent pain of different origin represent common medical, social, and economic burden, and its pharmacotherapy is still an unresolved issue. In order to achieve an optimised management of pain patients and to support the process of decision making in clinical practise, objective assessments of the treatment success are needed. Successful novel approaches for patient stratification could reduce the still high number of non-responders. Developing new analgesics is challenging because promising preclinical data are often not reproduced in the clinic, and often without knowing the reason. Improved pharmaco-dynamic biomarkers could define whether an intended target is adequately engaged, greatly reducing the risk in clinical development of a new drug. Finally, for many pain indications, there are no adequate preclinical models available, precluding preclinical investigations and leaving affected patients with little hope of relief. The goal of this Topic is to make advances in three pain areas in a complementary manner. These three Subtopics, each of which addresses a specific scientific challenge, together offer significant opportunities for cross-fertilisation:

Subtopic 3A: using Patient Reported Outcome Measures to improve the management of acute and chronic pain (PROMs);

Subtopic 3B: improving the translatability of pharmacodynamic biomarkers in pain pathways of healthy subjects and preclinical species (BIOM);

Subtopic 3C: improving translation in chronic pelvic pain (CPP).

Stage 1 short proposals from Applicants should address only one of these Subtopics. Applicants can submit a proposal to any of the subtopics and are not obliged to apply for all.

Whilst contributions to each subtopic will require mobilization of specialist expertise, it is a key objective of this Topic to create a research platform for pain that will contribute significantly to reduce fragmentation and generate highest impact on the whole area. Thus, to maximise cross-learnings and full data sharing while insuring economy of scale, it is envisaged that a single full proposal is submitted at stage 2. This full proposal will include activities covering all three subtopics, as well as overarching joint activities such us overall governance, communication and dissemination, and data and knowledge management.

Thus at Stage 2, the full proposal will be submitted by the consortium created by the merger of the winning Applicant Consortia of all subtopics (3A+3B+3C) with the Industry consortium.

Cele

Stage 1 short proposals from Applicants should address only one of the Subtopics. Applicants can submit a proposal to any of the subtopics and are not obliged to apply for all.

Whilst contributions to each subtopic will require mobilization of specialist expertise, it is a key objective of this Topic to create a research platform for pain that will contribute significantly to reduce fragmentation and generate highest impact on the whole area. Thus, to maximise cross-learnings and full data sharing while insuring economy of scale, it is envisaged that a single full proposal is submitted at stage 2. This full proposal will include activities covering all three subtopics, as well as overarching joint activities such as overall governance, communication and dissemination, and data and knowledge management.

Termin nadsyłania zgłoszeń

28 marzec 2017

Adres internetowy

https://ec.europa.eu/research/participants/portal/desktop/en/opportunities/h2020/topics/imi2-2016-10-03.html